| Date | Home | Away | Result |
|---|---|---|---|
| 16/09/25 17:45 | Athletic Bilbao | Arsenal FC | --- |
| 16/09/25 17:45 | PSV Eindhoven | Royale Union Saint-Gilloise | --- |
| 16/09/25 20:00 | Tottenham Hotspur | FC Villarreal | --- |
| 16/09/25 20:00 | Benfica Lisbon | Qarabag | --- |
| 16/09/25 20:00 | Juventus Turin | Borussia Dortmund | --- |
| 16/09/25 20:00 | Real Madrid | Olympique Marseille | --- |
| 17/09/25 17:45 | Olympiakos Piräus | Pafos FC | --- |
| 17/09/25 17:45 | Slavia Prag | FK Bodö/Glimt | --- |
| 17/09/25 20:00 | Paris St. Germain | Atalanta Bergamo | --- |
| 17/09/25 20:00 | Liverpool FC | Atletico Madrid | --- |
| 17/09/25 20:00 | Ajax Amsterdam | Inter Milan | --- |
| 17/09/25 20:00 | FC Bayern Munich | Chelsea FC | --- |
| 18/09/25 17:45 | Club Brugge | AS Monaco | --- |
| 18/09/25 17:45 | FC Copenhagen | Bayer 04 Leverkusen | --- |
| 18/09/25 20:00 | Sporting Lisbon | Qairat Almaty | --- |
| 18/09/25 20:00 | Eintracht Frankfurt | Galatasaray Istanbul | --- |
| 18/09/25 20:00 | Manchester City | SSC Napoli | --- |
| 18/09/25 20:00 | Newcastle United | FC Barcelona | --- |